Stages of Uterine Cancer

Uterine cancer, also known as endometrial cancer, is a type of cancer that develops in the lining of the uterus. It is the most common gynecologic cancer in women. Like many cancers, uterine cancer is categorized into different stages to help guide treatment and determine the prognosis. Staging is a crucial aspect of cancer diagnosis, providing valuable information about the extent of the disease. In this comprehensive guide, we will delve into the various stages of uterine cancer, exploring their characteristics, implications, and the significance of staging in the management of this disease.

Understanding Uterine Cancer:

Before delving into the stages of uterine cancer, it’s essential to have a basic understanding of the disease itself. Uterine cancer typically originates in the lining of the uterus, called the endometrium but can also develop from the muscle of the uterus.

Risk factors for uterine cancer include age, obesity, hormone replacement therapy, diabetes, and certain hereditary conditions. Recognizing symptoms such as abnormal vaginal bleeding, pelvic pain, and pain during intercourse is crucial for early detection.

Types of Uterine Cancer

There are different types of uterine cancer, and they are classified based on the specific cells or tissues within the uterus where the cancer begins. The main types include:

  • Endometrioid Adenocarcinoma:
    This is the most common type of uterine cancer, accounting for the majority of cases. It typically arises from the cells lining the uterus.
  • Serous Carcinoma:
    Serous carcinoma is a more aggressive and less common type of uterine cancer. It tends to grow and spread more quickly than endometrioid adenocarcinoma.
  • Clear Cell Carcinoma:
    Clear cell carcinoma is a less common subtype of uterine cancer. It is characterized by cells with clear cytoplasm and is often associated with a poorer prognosis.
  • Mixed Cell Carcinoma:
    Some uterine cancers may have a combination of different cell types, and these are classified as mixed cell carcinomas.
  • Uterine Sarcoma:
    Uterine sarcomas are rare cancers that originate in the muscles or other supporting tissues of the uterus. They include subtypes such as leiomyosarcoma and endometrial stromal sarcoma. Unlike the more common endometrial cancers, uterine sarcomas tend to have a poorer prognosis.

Stages of Uterine Cancer:

Stage Description
Stage I Confined to the uterine corpus and ovaryc
IA Disease limited to the endometrium OR non-aggressive histological type, i.e. low-grade endometroid, with invasion of less than half of myometrium with no or focal lymphovascular space involvement (LVSI) OR good prognosis disease
IA1 Non-aggressive histological type limited to an endometrial polyp OR confined to the endometrium
IA2 Non-aggressive histological types involving less than half of the myometrium with no or focal LVSI
IA3 Low-grade endometrioid carcinomas limited to the uterus and ovaryc
IB Non-aggressive histological types with invasion of half or more of the myometrium, and with no or focal LVSId
IC Aggressive histological typese limited to a polyp or confined to the endometrium
Stage II Invasion of cervical stroma without extrauterine extension OR with substantial LVSI OR aggressive histological types with myometrial invasion
IIA Invasion of the cervical stroma of non-aggressive histological types
IIB Substantial LVSId of non-aggressive histological types
IIC Aggressive histological typese with any myometrial involvement
Stage III Local and/or regional spread of the tumor of any histological subtype
IIIA Invasion of uterine serosa, adnexa, or both by direct extension or metastasis
IIIA1 Spread to ovary or fallopian tube (except when meeting stage IA3 criteria)c
IIIA2 Involvement of uterine subserosa or spread through the uterine serosa
IIIB Metastasis or direct spread to the vagina and/or to the parametria or pelvic peritoneum
IIIB1 Metastasis or direct spread to the vagina and/or the parametria
IIIB2 Metastasis to the pelvic peritoneum
IIIC Metastasis to the pelvic or para-aortic lymph nodes or bothf
IIIC1 Metastasis to the pelvic lymph nodes
IIIC1i Micrometastasis
IIIC1ii Macrometastasis
IIIC2 Metastasis to para-aortic lymph nodes up to the renal vessels, with or without metastasis to the pelvic lymph nodes
IIIC2i Micrometastasis
IIIC2ii Macrometastasis
Stage IV Spread to the bladder mucosa and/or intestinal mucosa and/or distance metastasis
IVA Invasion of the bladder mucosa and/or the intestinal/bowel mucosa
IVB Abdominal peritoneal metastasis beyond the pelvis
IVC Distant metastasis, including metastasis to any extra- or intra-abdominal lymph nodes above the renal vessels, lungs, liver, brain, or bone

Significance of Staging:

Understanding the stage of uterine cancer is crucial for several reasons:

  • Treatment Planning: Staging helps determine the most appropriate treatment plan. Early-stage cancers may be treated with surgery alone, while advanced stages may require a combination of surgery, radiation, and chemotherapy.
  • Prognosis: The stage of uterine cancer is a significant factor in predicting the likely outcome of the disease. Generally, the earlier the stage, the better the prognosis.
  • Clinical Trials: Staging guides the selection of patients for clinical trials investigating new treatments. This contributes to ongoing research and the development of more effective therapies.
  • Follow-up Care: Staging influences the intensity and frequency of follow-up care. Patients with higher-stage disease may require more vigilant monitoring to detect any recurrence or complications.


Uterine cancer stages play a crucial role in guiding treatment decisions, predicting outcomes, and advancing research in the field of oncology. A comprehensive understanding of the staging system empowers both healthcare professionals and patients to navigate the complex landscape of uterine cancer, fostering informed decision-making and personalized care. As research continues to evolve, the hope is that advancements in treatment modalities and early detection strategies will improve outcomes for individuals affected by uterine cancer.

Dr Timothy Lim is an experienced Specialist in Obstetrics and Gynaecology with a special interest in the management of gynaecological cancers. Please contact us for consultation at +65 98248180



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